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Explosion in sealed flask


The chemist had charged 3-methylaminopyridone hydrochloride into a 60ml bottle, with DMSO and excess DBU.  The bottle was sealed with a cap, and heated with a heat gun, with occasional shaking by hand.  After 3-4 minutes the dissolution of the amine hydrochloride was completed.  Suddenly a discolouration was observed, the heat was removed and the bottle placed in the fume cupboard with the sash window closed.  Effervescing was observed, followed by a loud bang, the lid of the bottle came off, and smoke was generated, and the distinct smell of thiol was observed.  There were no injuries.

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