Nitration Incident from solvent loss
Esterification of a nitrobenzyl alcohol with tartaric acid, the process involved heating the mixture in refluxing toluene to azeotropically remove the water. A slow loss of solvent later led to an explosion.
Once again, this shows the dangers of relying on a refluxing solvent for absolute temperature control. It is always desirable to have an automatic means of heating cut-out, in the event of solvent loss.
Investigation showed an instability above 180°C, which is typical for most nitro compounds.